The symptoms of restless fg42 replica legs syndrome (RLS) follow a circadian pattern, as inducated in the current RLS diagnostic criteria.Indeed, subjects with mild-to-moderate RLS suffer or not from RLS symptoms depending on the time of day, resembling an above-threshold state periodically followed by a below-threshold state.Although the circadian clock is crucial in the clinical features of RLS, research assessing drosselklappe stellantrieb the ultimate drivers of circadian rhythmicity is still very limited.In the present review, we show current evidence on circadian variations of neurotransmitters involved in the pathophysiology of RLS (systemic iron metabolism, brain iron homeostasis, adenosine, dopamine, glutamate, and endogenous opioids).
Secondly, an overview of available therapies for RLS is presented, including information on current recommendations for symptomatic treatments in RLS.